Calmodulin Lobotomized Novel Insights into Calcium Regulation of Voltage-Gated Calcium Channels

these two channel types (de Maria et al., 2001). Although activation (CDI). In this issue of Neuron, Liang et al. both motifs are also present in the C termini of the N-type present evidence to show that CDI is a much more and R-type calcium channel 1 subunits, CDI has not widely applicable feedback mechanism that limits caltypically been observed with these calcium channel subcium entry in response to rising intracellular calcium. types. An exciting study by Liang et al. (2003 [this issue